The domain within your query sequence starts at position 168 and ends at position 337; the E-value for the N6-adenineMlase domain shown below is 5.1e-11.
THAQYLFADRSCQFLAGLLATLGFSRVLCVGAPRLHEQIRLTASGERSGMRSLLLDIDFR YSQFYLEGSFCRYNMFNHHFFDGKAALEVCKEFLQEEEGKGVIMVTDPPFGGLVEPLAIT FKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFCMLDYQVD
N6-adenineMlase |
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PFAM accession number: | PF10237 |
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Interpro abstract (IPR041370): | This is a protein of approximately 200 residues which is conserved from plants to humans [ (PUBMED:7607512) ]. It contains a highly conserved QFW motif close to the N terminus and a DPPF motif in the centre. The DPPF motif is characteristic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes [ (PUBMED:16479578) ]. Proteins in this entry include EEF1A lysine methyltransferase 1 (EEF1AKMT1) and ZCCHC4. EEF1AKMT1 is a protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79' [ (PUBMED:26545399) ]. ZCCHC4 is an rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA [ (PUBMED:30531910) ]. |
GO function: | methyltransferase activity (GO:0008168) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry N6-adenineMlase