The domain within your query sequence starts at position 216 and ends at position 325; the E-value for the NIBRIN_BRCT_II domain shown below is 2.2e-34.



PFAM accession number:PF16508
Interpro abstract (IPR032429):

This entry represents the second BRCT domain of Nibrin (or Nbs1), a component of the MRN (Mre11-Rad50-Nbs1) complex that is involved in the DNA damage response. This domain (BRCT2) is identified through nuclear magnetic resonance (NMR) spectroscopy structure determination. It is downstream from BRCT1 domain and has no significant amino acid sequence homology to other BRCT domains. However, it has the alhpa/beta topology characteristic of BRCT domains in other proteins, but differs markedly in having a disordered long loop inserted between alpha beta strand and an alpha helix. BRCT2 is essential for an MDC1-dependent relocalisation of Nbs1 to DNA damage sites [ (PUBMED:18582474) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NIBRIN_BRCT_II