The domain within your query sequence starts at position 7 and ends at position 250; the E-value for the NmrA domain shown below is 3.9e-50.



PFAM accession number:PF05368
Interpro abstract (IPR008030):

NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA [ (PUBMED:18602114) ]. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. It lacks most of the active site residues of the SDR (short-chain dehydrogenases/reductases) family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG [ (PUBMED:11726498) ].

This domain can also be found in other atypical SDRs, such as HSCARG (an NADPH sensor) [ (PUBMED:18263583) ] and PCBER (phenylcoumaran benzylic ether reductase) [ (PUBMED:13129921) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NmrA