The domain within your query sequence starts at position 36 and ends at position 94; the E-value for the Nse4-Nse3_bdg domain shown below is 2.2e-20.



PFAM accession number:PF15412
Interpro abstract (IPR029225):

This entry represents the Nse3/MAGE ( IPR002190 ) binding domain found in NSE4/EID family proteins [ (PUBMED:22536443) (PUBMED:21364888) ].

Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [ (PUBMED:15987788) (PUBMED:15752197) (PUBMED:20571088) ]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors [ (PUBMED:15987788) ].

Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals [ (PUBMED:22536443) ]. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to the Nse3 (another SMC5-6 complex subunit) pocket [ (PUBMED:21364888) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Nse4-Nse3_bdg