The domain within your query sequence starts at position 930 and ends at position 977; the E-value for the Nuc_rec_co-act domain shown below is 2.3e-23.



PFAM accession number:PF08815
Interpro abstract (IPR014920):

This entry represents the interlocking domain of the eukaryotic nuclear receptor coactivators Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.

Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. In addition to their role as coactivators of various nuclear receptors, Ncoa1 and Ncoa3 both have histone acetyltransferase activity ( EC ), but Ncoa2 does not [ (PUBMED:14757047) (PUBMED:15145939) ].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO component:nucleus (GO:0005634)
GO function:transcription coactivator activity (GO:0003713), nuclear hormone receptor binding (GO:0035257)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Nuc_rec_co-act