The domain within your query sequence starts at position 69 and ends at position 265; the E-value for the P53 domain shown below is 1.1e-110.



PFAM accession number:PF00870
Interpro abstract (IPR011615):

This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [ (PUBMED:11780147) ]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [ (PUBMED:9630226) ]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.

P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [ (PUBMED:20066118) (PUBMED:12629332) (PUBMED:1397838) (PUBMED:6544917) (PUBMED:19826090) (PUBMED:19776744) (PUBMED:6278740) (PUBMED:221923) (PUBMED:6318442) (PUBMED:20030809) ].

GO function:transcription regulatory region sequence-specific DNA binding (GO:0000976)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry P53