The domain within your query sequence starts at position 322 and ends at position 424; the E-value for the PH_3 domain shown below is 2.3e-48.



PFAM accession number:PF14593
Interpro abstract (IPR033931):

This entry represents the pleckstrin homology (PH) domain from 3-phosphoinositide-dependent protein kinase 1 (PDK1) type proteins.

PDK1 plays an important role in insulin and growth factor signalling cascades. It phosphorylates and activates many AGC (cAMP-dependent, cGMP-dependent, protein kinase C (PKC)) family of protein kinases members, including protein kinase B (PKB, also known as Akt), p70 ribosomal S6-kinase (S6K), serum and glucocorticoid responsive kinase (SGK), p90 ribosomal S6 kinase (RSK), and PKC [ (PUBMED:15457207) ]. PDK1 contains an N-terminal serine/threonine kinase domain followed by a PH domain. Following binding of the PH domain to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, PDK1 activates these enzymes by phosphorylating a Ser/Thr residue in their activation loop. [ (PUBMED:18347057) (PUBMED:15003271) (PUBMED:10698680) (PUBMED:11897568) ].

Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [ (PUBMED:14594214) (PUBMED:12694559) (PUBMED:21119626) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PH_3