SMART: Pfam domain PPAK

The domain within your query sequence starts at position 11454 and ends at position 11480; the E-value for the PPAK domain shown below is 7.1e-10.

PPPKVPEVPKKIIQEEKLPVVLPEDTE

PPAK

PFAM accession number:	PF02818
Interpro abstract (IPR004168):	PPAK is a repeated protein motif found in the PEVK (Pro-Glu-Val-Lys) domain of the titin protein and in a number of other proteins. Titin ( EC 2.7.11.1 ) is a giant elastic protein found in striated muscle that is a key component in the assembly and functioning of sarcomeres [ (PUBMED:15507486) ]. PPAK motifs (PPAK refers to the four amino acids found at the beginning of the motif) occur 60 times in human soleus titin [ (PUBMED:11276084) ]. PPAK motifs occur in groups of 2-12 that are separated by regions rich in glutamic acid (approximately 45%) and termed polyE segments. The charge fluctuation between the PPAK and polyE regions suggests ionic interactions between these segments and their involvement in the elastic function of titin.

PFAM accession number:

PF02818

Interpro abstract (IPR004168):

PPAK is a repeated protein motif found in the PEVK (Pro-Glu-Val-Lys) domain of the titin protein and in a number of other proteins. Titin ( EC 2.7.11.1 ) is a giant elastic protein found in striated muscle that is a key component in the assembly and functioning of sarcomeres [ (PUBMED:15507486) ]. PPAK motifs (PPAK refers to the four amino acids found at the beginning of the motif) occur 60 times in human soleus titin [ (PUBMED:11276084) ]. PPAK motifs occur in groups of 2-12 that are separated by regions rich in glutamic acid (approximately 45%) and termed polyE segments. The charge fluctuation between the PPAK and polyE regions suggests ionic interactions between these segments and their involvement in the elastic function of titin.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PPAK