The domain within your query sequence starts at position 1 and ends at position 115; the E-value for the PROL5-SMR domain shown below is 9.4e-41.



PFAM accession number:PF15621
Interpro abstract (IPR026288):

This entry includes submaxillary gland androgen-regulated proteins SMR1,SMR2, SMR3. This entry also includes opiorphin prepropeptide from humans.

SMR1 gene gives rise to four related peptides: SMR1-undecapeptide, SMR1-hexapeptide, SMR1-pentapeptide [ (PUBMED:8112327) ] and submandibular gland peptide T [ (PUBMED:9321881) ].

Submandibular gland peptide T is able to down-regulate cardiovascular depression induced by septic or anaphylactic shock [ (PUBMED:9321881) ].

SMR1-pentapeptide (also called Sialorphin) may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation. It is synthesized predominantly in the submandibular gland and prostate of adult rats in response to androgen steroids and is released locally and systemically in response to stress. It is an endogenous inhibitor of neprilysin. It inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. It has an analgesic effect when administered to rats by intravenous injection [ (PUBMED:9321881) (PUBMED:9362294) (PUBMED:12835417) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PROL5-SMR