The domain within your query sequence starts at position 1 and ends at position 330; the E-value for the Pannexin_like domain shown below is 3.8e-143.

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHES
RENISGAPCQQLLPQGISEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPY
LVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPASG
RAMVTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSEPPVVTLLDKKEGEQAKALFEKVKKF
RVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCC
NHTKAHLFSKLAFCYISFVCVYGITCLYTL

Pannexin_like

Pannexin_like
PFAM accession number:PF12534
Interpro abstract (IPR021040):

This entry represents the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space [ (PUBMED:22532330) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Pannexin_like