SMART: Pfam domain Peptidase

The domain within your query sequence starts at position 80 and ends at position 344; the E-value for the Peptidase_C101 domain shown below is 4.7e-129.

LSVAPEMDIMDYCKKEWRGNTQKATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQAM
SQLAELPPWLQDLELILLPEKLINKYTWIKQWKLGLKFDGKSEDLVEKIKESLALLRKKW
VSLAAMKTAEARQTACDELFTNEEEEYSLYEAVKFLMLNRAIELYDDKEKGKEVPFFSVL
LFARDTSNDPEQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHSIRVYRLSKYNTEEFITVY
PTDPPKDWPMVTLIAEDDRHYNIPV

Peptidase_C101

PFAM accession number:	PF16218
Interpro abstract (IPR023235):	This entry represents the FAM105 family, including FAM105A (OTULINL) and FAM105B (OTULIN). Otulin is an ubiquitin thioesterase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response [ (PUBMED:23708998) ]. FAM105A shares a high degree of similarity with protein otulin; however, FAM105A lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity [ (PUBMED:23708998) ].

PFAM accession number:

PF16218

Interpro abstract (IPR023235):

This entry represents the FAM105 family, including FAM105A (OTULINL) and FAM105B (OTULIN). Otulin is an ubiquitin thioesterase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response [ (PUBMED:23708998) ]. FAM105A shares a high degree of similarity with protein otulin; however, FAM105A lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity [ (PUBMED:23708998) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Peptidase_C101