The domain within your query sequence starts at position 309 and ends at position 420; the E-value for the Pribosyltran domain shown below is 1.3e-9.



PFAM accession number:PF00156
Interpro abstract (IPR000836):

This entry refers to the phosphoribosyl transferase (PRT) type I domain. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrpphosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. This domain is found in a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC ribose-phosphate pyrophosphokinase EC amidophosphoribosyltransferase EC orotate phosphoribosyltransferase EC uracil phosphoribosyltransferase EC and xanthine-guanine phosphoribosyltransferase EC . In Arabidopsis, at the very N terminus of this domain is the P-Loop NTPase domain [ (PUBMED:17143579) (PUBMED:11751055) (PUBMED:18550080) (PUBMED:15689504) (PUBMED:18399692) (PUBMED:12808089) (PUBMED:8894695) (PUBMED:22075667) (PUBMED:15096496) (PUBMED:7030616) (PUBMED:6105839) (PUBMED:21366534) (PUBMED:18535147) ].

GO process:nucleoside metabolic process (GO:0009116)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Pribosyltran