The domain within your query sequence starts at position 578 and ends at position 632; the E-value for the Rad21_Rec8 domain shown below is 2.4e-25.



PFAM accession number:PF04824
Interpro abstract (IPR006909):

This domain represents a conserved C-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Rad21/Rec8 like proteins mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex [ (PUBMED:11687503) ]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation [ (PUBMED:10207075) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Rad21_Rec8