The domain within your query sequence starts at position 70 and ends at position 166; the E-value for the Rieske_2 domain shown below is 1.4e-10.



PFAM accession number:PF13806
Interpro abstract (IPR012748):

In Proteobacteria and Actinobacteria the main nitrite reductase activity is contributed by the NADH-dependent nitrite reductase, which detoxifies the nitrite formed as the product of nitrate reduction. The NADH-nitrite reductase operon consists of 4 genes: nirB, nirD, nirC and cysG. The enzyme is formed by the two subunits nirB and nirD. NirC is a nitrite transporter and cysG is required for the synthesis of sirohaem, a cofactor of the nirB subunit [ (PUBMED:8919448) (PUBMED:2200672) ]. NirD displays some sequence similarities with the 2Fe-2S Rieske domain but it does not contain the essential residues for the coordination of the iron sulphur [ (PUBMED:11460929) (PUBMED:16271700) ].

The entry includes the NirD subunit. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while fungal proteins have a C-terminal Rieske domain in addition to several other domains. The fungal NirD is involved in nutrient acquisition, functioning at the soil/fungus interface to control nutrient exchange between the fungus and the host plant [ (PUBMED:8694757) (PUBMED:12665993) ]. The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs [ (PUBMED:16168954) ]. In this family, only a few members contain these residues. Other members may have lost the ability to bind the Rieske [2Fe-2S] cluster.

GO process:oxidation-reduction process (GO:0055114)
GO function:nitrite reductase [NAD(P)H] activity (GO:0008942)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Rieske_2