The domain within your query sequence starts at position 32 and ends at position 217; the E-value for the SBF domain shown below is 3.3e-47.



PFAM accession number:PF01758
Interpro abstract (IPR002657):

This family of proteins are found both in prokaryotes and eukaryotes. They are related to the human bile acid:sodium symporters (TC 2.A.28), which are transmembrane proteins functioning in the liver in the uptake of bile acids from portal blood plasma, a process mediated by the co-transport of Na + [ (PUBMED:1961729) ].

This entry also includes members of the ACR3 family of arsenite (As(III)) permeases, which confer resistance to arsenic by extrusion from cells [ (PUBMED:19494117) ]. They exist in prokaryotes and eukaryotes (lower plants and fungi) [ (PUBMED:20530755) (PUBMED:24291645) ]. The ACR3 permeases have ten-transmembrane span topology [ (PUBMED:18088595) ]. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 is thought to be an antiporter that catalyses arsenite-proton exchange [ (PUBMED:22102279) ].

The Shewanella oneidensis Acr3 is not able to transport As(III) and confers resistance only to arsenate (As(V)) [ (PUBMED:19039703) ], whereas the Acr3 orthologue from Synechocystis mediates tolerance to As(III), As(V) and antimonite (Sb(III)) [ (PUBMED:12949088) ].

In budding yeast, overexpression of the Acr3 gene confers an arsenite- but not an arsenate-resistance phenotype [ (PUBMED:9234670) ]. Saccharomyces cerevisiae Acr3 is a plasma membrane metalloid/H+ antiporter that transports arsenite and antimonite [ (PUBMED:21447319) ].

GO component:membrane (GO:0016020)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SBF