The domain within your query sequence starts at position 22 and ends at position 416; the E-value for the STIL_N domain shown below is 1.5e-180.



PFAM accession number:PF15253
Interpro abstract (IPR026123):

SIL (also called STIL/TAL1 interrupting locus) is an immediate-early gene that is essential for embryonic development and is implicated in T-cell leukemia-associated translocations [ (PUBMED:12006978) (PUBMED:8825637) ]. Sil protein is necessary for proper mitotic spindle organisation in zebrafish and human cells and localizes to the mitotic spindle poles only during metaphase [ (PUBMED:17576815) ]. Mouse Sil was suggested to play a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 [ (PUBMED:11668681) ]. In human, cell cycle-dependent phosphorylation of Sil is required for its interaction with Pin1, a regulator of mitosis [ (PUBMED:16024801) ].

Primary microcephaly (MCPH) is an autosomal-recessive congenital disorder characterised by smaller-than-normal brain size and mental retardation. Three different homozygous mutations in SIL were identified in patients from three of the five families linked to the MCPH7 locus; all are predicted to truncate the Sil protein [ (PUBMED:19215732) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry STIL_N