SMART: Pfam domain Sam68-YY

The domain within your query sequence starts at position 267 and ends at position 321; the E-value for the Sam68-YY domain shown below is 1.3e-22.

YEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEE

Sam68-YY

PFAM accession number:	PF16568
Interpro abstract (IPR032335):	This entry represents a tyrosine-rich domain found in Sam68, also known as KH domain-containing, RNA-binding, signal transduction-associated protein. Sam68 regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with this domain to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumour-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes [ (PUBMED:22000517) ].

PFAM accession number:

PF16568

Interpro abstract (IPR032335):

This entry represents a tyrosine-rich domain found in Sam68, also known as KH domain-containing, RNA-binding, signal transduction-associated protein. Sam68 regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with this domain to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumour-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes [ (PUBMED:22000517) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Sam68-YY