The domain within your query sequence starts at position 437 and ends at position 681; the E-value for the Sec23_trunk domain shown below is 3.6e-88.



PFAM accession number:PF04811
Interpro abstract (IPR006896):

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [ (PUBMED:11535824) ]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation [ (PUBMED:12239560) ].

Sec23 p and Sec24p are structurally related, folding into five distinct domains: a beta-barrel, a zinc-finger ( IPR006895 ), an alpha/beta trunk domain, an all-helical region ( IPR006900 ), and a C-terminal gelsolin-like domain ( IPR007123 ). This entry describes the Sec23/24 alpha/beta trunk domain, which is formed from a single, approximately 250-residue segment plugged into the beta-barrel between strands beta-1 and beta-19. The trunk has an alpha/beta fold with a vWA topology, and it forms the dimer interface, primarily involving strand beta-14 on Sec23 and Sec24; in addition, the trunk domain of Sec23 contacts Sar1.

GO process:intracellular protein transport (GO:0006886), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)
GO component:COPII vesicle coat (GO:0030127)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Sec23_trunk