The domain within your query sequence starts at position 19 and ends at position 147; the E-value for the Shadoo domain shown below is 7.2e-71.
CDSCSAKGGRGGARGSARGVRGGARGASRVRVRPAPRYGSSLRVAAAGAAAGAAAGVAAG LATGSGWRRTSGPGELGLEDDENGAMGGNGTDRGVYSYWAWTSGSGSVHSPRICLLLGGT LGALELLRP
Shadoo |
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PFAM accession number: | PF14999 |
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Interpro abstract (IPR029238): | This family of prion-like proteins has a neuroprotective function, similar to PrP(C)-like [ (PUBMED:17703189) ]. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal prion protein (PrP) which lead to lethal neurodegenerative diseases [ (PUBMED:14527721) ]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich. |
GO component: | anchored component of membrane (GO:0031225) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Shadoo