SMART: Pfam domain Symplekin

The domain within your query sequence starts at position 887 and ends at position 1068; the E-value for the Symplekin_C domain shown below is 4.3e-78.

DVRFLIPVLNGLEKKEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELL
IALHNIDSVKCDMKSIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSL
TMYPRLGGFVMNILARLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFD
KC

Symplekin_C

PFAM accession number:	PF12295
Interpro abstract (IPR022075):	This domain is found in symplekin. It is approximately 180 amino acids in length and contains a single completely conserved residue P that may be functionally important. Symplekin has been localised, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Further analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited to the plaque structure of the zonula occludens [ (PUBMED:8769423) ].

PFAM accession number:

PF12295

Interpro abstract (IPR022075):

This domain is found in symplekin. It is approximately 180 amino acids in length and contains a single completely conserved residue P that may be functionally important.

Symplekin has been localised, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Further analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited to the plaque structure of the zonula occludens [ (PUBMED:8769423) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Symplekin_C