The domain within your query sequence starts at position 227 and ends at position 313; the E-value for the TBP domain shown below is 3.4e-35.
FLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGK VVLTGAKVRAEIYEAFENIYPILKGFR
TBP |
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PFAM accession number: | PF00352 |
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Interpro abstract (IPR000814): | The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box [ (PUBMED:12782648) (PUBMED:10974559) ]. TBP associates with a host of factors, including the general transcription factors SL1, TFIIA, -B, -D, -E, and -H, to form huge multi-subunit pre-initiation complexes on the core promoter. Through its association with different transcription factors, TBP can initiate transcription from different RNA polymerases. There are several related TBPs, including TBP-like (TBPL) proteins [ (PUBMED:12878007) ]. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. The C-terminal core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box and interacts with transcription factors and regulatory proteins [ (PUBMED:1436073) ]. By contrast, the N-terminal region varies in both length and sequence. |
GO process: | DNA-templated transcription, initiation (GO:0006352) |
GO function: | DNA binding (GO:0003677) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry TBP