The domain within your query sequence starts at position 61 and ends at position 195; the E-value for the TFIID_NTD2 domain shown below is 8.4e-35.



PFAM accession number:PF04494
Interpro abstract (IPR007582):

The TATA Binding Protein (TBP) Associated Factor 5 (TAF5) is one of several TAFs that bind TBP and are involved in forming Transcription Factor IID (TFIID) complex. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID [ (PUBMED:10664584) ].

This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly [ (PUBMED:17227857) ]. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 (second N-terminal domain) and N-terminal domain are crucial for homodimerisation [ (PUBMED:17397863) ]. TAF5 has a paralogue gene (TAF5L) which has a redundant function [ (PUBMED:16206511) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TFIID_NTD2