The domain within your query sequence starts at position 722 and ends at position 1196; the E-value for the TIMELESS_C domain shown below is 4.4e-187.
MLHRLAHGLGMEALLFQLSLFCLFNRLLSDPAAAAYKELVTFAKYIIGKFFALAAVNQKA FVELLFWKNTAVVREMTQGYGSLDSGSSSHRAPLWSPEEEAQLQELYLAHKDVEGQDVVE TILAHLKVVPRTRKQVIHHLVRMGLADSVKEFQKRKGTQIVLWTEDQELELQRLFEEFRD SDDVLGQIMKNITAKRSRARVVDKLLALGLVSERRQLYKKRRKKLAPSCMNGEKSPRDPW QEDPEEEDEHLPEDESEDEESEEGLPSGQGQGSSSLSAENLGESLRQEGLSAPLLWLQSS LIRAANDREEDGCSQAIPLVPLTEENEEAMENEQFQHLLRKLGIRPPSSGQETFWRIPAK LSSTQLRRVAASLSQQENEEEREEEPEPGVPGEQGPSEEHRTEALRALLSARKRKAGLGP TEEEATGEEEWNSAPKKRQLLDSDEEEDDEGRRQAVSGTPRVHRKKRFQIEDEDD
TIMELESS_C |
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PFAM accession number: | PF05029 |
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Interpro abstract (IPR007725): | The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2) [ (PUBMED:11237000) ]. mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function [ (PUBMED:10903565) ]. Some family members contain a SANT domain in this region. This domain found in hTIM has been shown to bind to the PARP-1 catalytic domain. The Timeless-PARP-1 complex is involved in homologous recombination repair [ (PUBMED:26344098) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry TIMELESS_C