The domain within your query sequence starts at position 423 and ends at position 533; the E-value for the TMC domain shown below is 2.5e-42.



PFAM accession number:PF07810
Interpro abstract (IPR012496):

These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 ( Q7TN63 ) and EVIN2 ( Q8IU68 ) - this region is termed the TMC domain [ (PUBMED:12906855) ]. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis [ (PUBMED:12906855) ]. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters [ (PUBMED:12812529) ].

GO component:integral component of membrane (GO:0016021)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TMC