SMART: Pfam domain TNFR

The domain within your query sequence starts at position 44 and ends at position 66; the E-value for the TNFR_c6 domain shown below is 1.1e-7.

CPQGKYVHSKNNSICCTKCHKG

TNFR_c6

PFAM accession number:	PF00020
Interpro abstract (IPR001368):	A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [ (PUBMED:2174582) (PUBMED:15335933) (PUBMED:15335677) ]: Tumor Necrosis Factor type I and type II receptors (TNFR). Both receptors bind TNF-alpha and TNF-beta, but are only similar in the cysteine-rich region. TNFR contains four cysteine-rich domain modules (CRDs), termed CRD1 through CRD4. CRD2 and CRD3 are known as TNF-binding domains [ (PUBMED:8387891) ]. Shope fibroma virus soluble TNF receptor (protein T2) Lymphotoxin alpha/beta receptor Low-affinity nerve growth factor receptor (LA-NGFR) (p75) CD40 (Bp50), the receptor for the CD40L (or TRAP) cytokine CD27, the receptor for the CD27L cytokine CD30, the receptor for the CD30L cytokine T-cell protein 4-1BB, the receptor for the 4-1BBL putative cytokine FAS antigen (or APO-1), the receptor for FASL, a protein involved in apoptosis (programmed cell death) T-cell antigen OX40, the receptor for the OX40L cytokine Wsl-1, a receptor (for a yet undefined ligand) that mediates apoptosis Vaccinia virus protein A53 (SalF19R) It has been shown [ (PUBMED:8387891) ] that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below: +-------------+ +--------------+ \| \| \| \| xCxxxxxxxxxxxxxCxCxxCxxxxxxxxxCxxxxCxx \| \| +------------+ 'C': conserved cysteine involved in a disulphide bond.
GO function:	protein binding (GO:0005515)

PFAM accession number:

PF00020

Interpro abstract (IPR001368):

A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [ (PUBMED:2174582) (PUBMED:15335933) (PUBMED:15335677) ]:

Tumor Necrosis Factor type I and type II receptors (TNFR). Both receptors bind TNF-alpha and TNF-beta, but are only similar in the cysteine-rich region. TNFR contains four cysteine-rich domain modules (CRDs), termed CRD1 through CRD4. CRD2 and CRD3 are known as TNF-binding domains [ (PUBMED:8387891) ].
Shope fibroma virus soluble TNF receptor (protein T2)
Lymphotoxin alpha/beta receptor
Low-affinity nerve growth factor receptor (LA-NGFR) (p75)
CD40 (Bp50), the receptor for the CD40L (or TRAP) cytokine
CD27, the receptor for the CD27L cytokine
CD30, the receptor for the CD30L cytokine
T-cell protein 4-1BB, the receptor for the 4-1BBL putative cytokine
FAS antigen (or APO-1), the receptor for FASL, a protein involved in apoptosis (programmed cell death)
T-cell antigen OX40, the receptor for the OX40L cytokine
Wsl-1, a receptor (for a yet undefined ligand) that mediates apoptosis
Vaccinia virus protein A53 (SalF19R)

It has been shown [ (PUBMED:8387891) ] that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below:


                  +-------------+    +--------------+
                  |             |    |              |
                 xCxxxxxxxxxxxxxCxCxxCxxxxxxxxxCxxxxCxx
                                  |            |
                                  +------------+

'C': conserved cysteine involved in a disulphide bond.

GO function:

protein binding (GO:0005515)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TNFR_c6