The domain within your query sequence starts at position 50 and ends at position 215; the E-value for the TPH domain shown below is 1.5e-11.



PFAM accession number:PF13868
Interpro abstract (IPR043597):

Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells [ (PUBMED:15731013) ]. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation [ (PUBMED:18931701) ].

This entry represents the trichohyalin-plectin-homology domain. This domain can be found in mitostatin (also known as trichoplein keratin filament-binding protein, TCHP) and related proteins [ (PUBMED:15731013) (PUBMED:18931701) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TPH