The domain within your query sequence starts at position 108 and ends at position 250; the E-value for the TPP_enzyme_C domain shown below is 5.9e-8.

DLEGHPTPRLSFVDVATGSLGQGLGAACGMAYTGKYFDKASYRVFCLMGDGESSEGSVWE
ALAFASHYNLDNLVAIFDVNRLGQSGTAPLEHCTAVYEKRCQAFGWNTYVVDGHDVEALC
QAFWKAAQVKNKPTALIAKTFKG

TPP_enzyme_C

TPP_enzyme_C
PFAM accession number:PF02775
Interpro abstract (IPR011766):

A number of enzymes require thiamine pyrophosphate (TPP) (vitamin B1) as a cofactor. It has been shown [ (PUBMED:8604141) ] that some of these enzymes are structurally related. This represents the C-terminal TPP binding domain of TPP enzymes.

GO function:catalytic activity (GO:0003824), thiamine pyrophosphate binding (GO:0030976)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TPP_enzyme_C