The domain within your query sequence starts at position 661 and ends at position 717; the E-value for the TPX2 domain shown below is 6.3e-19.



PFAM accession number:PF06886
Interpro abstract (IPR027329):

This entry represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [ (PUBMED:8548825) (PUBMED:10871281) ]. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way [ (PUBMED:10871281) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TPX2