The domain within your query sequence starts at position 61 and ends at position 138; the E-value for the TRAM_LAG1_CLN8 domain shown below is 7.8e-14.



PFAM accession number:PF03798
Interpro abstract (IPR006634):

TLC is a protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis [ (PUBMED:11694577) ], TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains [ (PUBMED:9872981) ].

GO component:integral component of membrane (GO:0016021)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TRAM_LAG1_CLN8