The domain within your query sequence starts at position 247 and ends at position 588; the E-value for the Tcf25 domain shown below is 2.3e-113.

FFAFDHNEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMAR
DLIERALYSMECAFHPLFSLTSGTCRLDYRRPENRSFYLTLYKQMSFLEKRGCPRTALEY
CKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAY
FLLSQQTDLPEHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPD
AEISQPPALGQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLQAVDAGDPAVEACENRRKV
LYQRAPRNIHRHVILSEIKEAVAALPSDVTTQSVMGFDPLPP

Tcf25

Tcf25
PFAM accession number:PF04910
Interpro abstract (IPR006994):

This entry includes TCF25 from animals and Rqc1 from budding yeasts. Rqc1 is a component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation [ (PUBMED:23178123) ]. TCF25 may act by increasing histone deacetylase activity at promoter regions [ (PUBMED:16574069) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Tcf25