The domain within your query sequence starts at position 28 and ends at position 70; the E-value for the Trefoil domain shown below is 3.6e-12.



PFAM accession number:PF00088
Interpro abstract (IPR000519):

A cysteine-rich domain of approximately forty five amino-acid residues has been found in some extracellular eukaryotic proteins [ (PUBMED:7820556) (PUBMED:9187350) (PUBMED:8518738) (PUBMED:8267796) ]. It is known as either the 'P', 'trefoil' or 'TFF' domain, and contains six cysteines linked by three disulphide bonds with connectivity 1-5, 2-4, 3-6. This leads to a characteristic three leafed structure ('trefoil'). The P-type domain is clearly composed of three looplike regions. The central core of the domain consists of a short two-stranded antiparallel beta-sheet, which is capped by an irregular loop and forms a central hairpin (loop 3). The beta-sheet is preceded by a short alpha-helix, with majority of the remainder of the domain contained in two loops, which lie on either side of the central hairpin.

This domain has been found in a variety of extracellular eukaryotic proteins [ (PUBMED:7820556) (PUBMED:8518738) (PUBMED:8267796) ], including:

  • protein pS2 (TFF1), a protein secreted by the stomach mucosa
  • spasmolytic polypeptide (SP) (TFF2), a protein of about 115 residues that inhibits gastrointestinal motility and gastric acid secretion
  • intestinal trefoil factor (ITF) (TFF3)
  • Xenopus laevis stomach proteins xP1 and xP4
  • xenopus integumentary mucins A.1 (FIM-A.1 or preprospasmolysin) and C.1 (FIM-C.1), proteins which may be involved in defence against microbial infections by protecting the epithelia from the external environment
  • xenopus skin protein xp2 (or APEG)
  • Zona pellucida sperm-binding protein B (ZP-B)
  • intestinal sucrase-isomaltase ( EC / EC ), a vertebrate membrane bound, multifunctional enzyme complex which hydrolyses sucrose, maltose and isomaltose
  • lysosomal alpha-glucosidase ( EC )

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Trefoil