The domain within your query sequence starts at position 49 and ends at position 334; the E-value for the Trp_Tyr_perm domain shown below is 3.4e-12.



PFAM accession number:PF03222
Interpro abstract (IPR018227):

Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ (PUBMED:3146645) (PUBMED:2687114) (PUBMED:8382989) ].

Aromatic amino acids are concentrated in the cytoplasm of Escherichia coli by 4 distinct transport systems: a general aromatic amino acid permease, and a specific permease for each of the 3 types (Phe, Tyr and Trp) [ (PUBMED:1987112) ]. It has been shown [ (PUBMED:2022620) ] that some permeases in E. coli and related bacteria are evolutionary related. These permeases are proteins of about 400 to 420 amino acids and are located in the cytoplasmic membrane and, like bacterial sugar/cation transporters, are thought to contain 12 transmembrane (TM) regions [ (PUBMED:1987112) ] - hydropathy analysis, however, is inconclusive, suggesting the possibility of 10 to 12 membrane-spanning domains [ (PUBMED:2022620) ]. The best conserved domain is a stretch of 20 residues which seems to be located in a cytoplasmic loop between the first and second transmembrane region.

GO process:amino acid transmembrane transport (GO:0003333)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Trp_Tyr_perm