The domain within your query sequence starts at position 182 and ends at position 368; the E-value for the Trypsin domain shown below is 5.5e-15.
KVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGAR YEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIV STTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPS DRIRQFL
Trypsin |
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PFAM accession number: | PF00089 |
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Interpro abstract (IPR001254): | This entry represents the active-site-containing domain found in the trypsin family members. The catalytic activity of the serine proteases from the trypsin family is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which itself is hydrogen-bonded to a serine. The sequences in the vicinity of the active site serine and histidine residues are well conserved in this family of proteases [ (PUBMED:3136396) ]. A partial list of proteases known to belong to the trypsin family is shown below.
All the above proteins belong to family S1 in the classification of peptidases [ (PUBMED:7845208) ] and originate from eukaryotic species. It should be noted that bacterial proteases that belong to family S2A are similar enough in the regions of the active site residues that they can be picked up by the same patterns. These proteases are listed below.
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GO process: | proteolysis (GO:0006508) |
GO function: | serine-type endopeptidase activity (GO:0004252) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Trypsin