The domain within your query sequence starts at position 102 and ends at position 113; the E-value for the Urotensin_II domain shown below is 4e-8.



PFAM accession number:PF02083
Interpro abstract (IPR001483):

Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord but later found in humans and other mammals [ (PUBMED:10499587) ]. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems [ (PUBMED:3724202) ]. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta [ (PUBMED:10499587) (PUBMED:11020490) (PUBMED:15102493) ].

This entry represents urotensin II.

GO process:regulation of blood pressure (GO:0008217), regulation of blood vessel diameter (GO:0097746)
GO component:extracellular region (GO:0005576)
GO function:hormone activity (GO:0005179)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Urotensin_II