The domain within your query sequence starts at position 47 and ends at position 291; the E-value for the Vasohibin domain shown below is 1.1e-124.



PFAM accession number:PF14822
Interpro abstract (IPR028131):

This entry represents a family of tubulinyl-Tyr carboxypeptidases. These regulate microtubule function by removing a C-terminal tyrosine residue from alpha-tubulin [ (PUBMED:29146869) ]. Tubulinyl-Tyr carboxypeptidase 1 is also known as vasohibin-1 (VASH1), and it act as an angiogenesis inhibitor [ (PUBMED:15467828) (PUBMED:17095714) ]. VASH1 is predominantly expressed in endothelial cells and it is induced by vascular endothelial growth factor (VEGF) or fibroblast growth factor 2 (FGF-2). Tubulinyl-Tyr carboxypeptidase 2 (VASH2) is thought to be expressed in cells other than endothelial cells [ (PUBMED:16528006) (PUBMED:23100270) ].

Angiogenesis, the formation of new vessels from existing ones, is a key event both under physiological and pathologic conditions. It is determined by the local balance between angiogenesis stimulators and inhibitors.

GO process:regulation of angiogenesis (GO:0045765)
GO component:cytoplasm (GO:0005737)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Vasohibin