The domain within your query sequence starts at position 15 and ends at position 753; the E-value for the Vps35 domain shown below is 6.8e-303.
LLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDEL HYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLV EMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLW VRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCR DALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHRED GPGIPAEIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLE TTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRK SMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRF IHLLRSDDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWE KKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLY EDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCA HLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKE NDAVTIQVLNQLIQKIRED
Vps35 |
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PFAM accession number: | PF03635 |
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Interpro abstract (IPR005378): | Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [ (PUBMED:11598206) (PUBMED:25937119) ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo [ (PUBMED:23148298) ]. Mutations in the Vps35 gene have been linked to Parkinson's disease [ (PUBMED:25416282) ]. Structurally, VPS35 forms a horseshoe-shaped, right-handed, alpha-helical solenoid [ (PUBMED:17891154) ]. This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes. |
GO process: | protein transport (GO:0015031), retrograde transport, endosome to Golgi (GO:0042147) |
GO component: | retromer, cargo-selective complex (GO:0030906) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Vps35