The domain within your query sequence starts at position 574 and ends at position 588; the E-value for the Xin domain shown below is 2.1e-8.
GGVSRAKWLFETQPL
Xin |
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| PFAM accession number: | PF08043 |
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| Interpro abstract (IPR012510): | The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD. This repeat motif is typically found in the N terminus of the proteins, with a copy number between 2 and 28 repeats. Direct evidence for binding to and stabilising F-actin has been found in the human protein ( Q702N9 ) [ (PUBMED:16631741) ]. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane [ (PUBMED:16631741) ]. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filamin C [ (PUBMED:12203715) ]. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins. |
| GO process: | actin cytoskeleton organization (GO:0030036) |
| GO component: | cell junction (GO:0030054) |
| GO function: | actin binding (GO:0003779) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Xin