The domain within your query sequence starts at position 660 and ends at position 761; the E-value for the tRNA-synt_1e domain shown below is 2.8e-7.



PFAM accession number:PF01406
Interpro abstract (IPR032678):

This entry represents the catalytic (Rossmann-fold) domain found in cysteinyl tRNA synthetases [ (PUBMED:22184460) ] which is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.

Cysteine-tRNA ligase (also known as cysteinyl-tRNA synthetase) ( EC ) is an alpha monomer and belongs to class Ia [ (PUBMED:1992490) ]. It aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. It is highly specific despite not possessing the amino acid editing activity characteristic of many other tRNA ligases [ (PUBMED:12032090) (PUBMED:10704480) (PUBMED:12458790) (PUBMED:10447505) (PUBMED:7647112) (PUBMED:14665676) (PUBMED:7783224) (PUBMED:11550797) (PUBMED:11310981) (PUBMED:8274143) (PUBMED:2203971) (PUBMED:7479698) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry tRNA-synt_1e