The domain within your query sequence starts at position 23 and ends at position 87; the E-value for the zf-Tim10_DDP domain shown below is 4.6e-26.
MEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSR AYNSR
zf-Tim10_DDP |
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PFAM accession number: | PF02953 |
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Interpro abstract (IPR004217): | This domain has four conserved cysteine residues. It is found in proteins Tim8, Tim9, Tim10 and Tim13, which are involved in mitochondrial protein import [ (PUBMED:11101512) ] and seem to be localised to the mitochondrial intermembrane space. The Tim8-Tim13 complex has a complex architecture, similar to the Tim9-Tim10 complex, composed of a hexametric architecture with long helices which look like tentacles extend from a central loop [ (PUBMED:18706423) ]. In each subunit of the Tim9-Tim10 complex, a signature "twin CX3C" motif forms two intramolecular disulfides [ (PUBMED:16387659) ]. Defects in the Tim8A gene (DDP1) have been shown to be the cause of 2 human syndromes: Mohr-Tranebjaerg syndrome (MTS); also known as dystonia-deafness syndrome (DDS) or X-linked progressive deafness type 1 (DFN-1); and Jensen syndrome (JENSS); also known as opticoacoustic nerve atrophy with dementia. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry zf-Tim10_DDP