RPEL Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
SMART ACC:	SM000707
Description:	-
InterPro ACC:	IPR004018
InterPro abstract:	RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be … expand RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [ PUBMED:12732141 PUBMED:15620697 ]. Some proteins known to contain RPEL repeats are listed below: Mammalian myocardin, heart-specific serum response factor (SRF) co- activator. Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator. Vertebrate myocardin-related transcription factor B (MRTF-B). Mammalian phosphatase and actin regulator 1 to 3. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 16 001 RPEL domains in 4 997 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing RPEL domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing RPEL domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a RPEL domain which could be assigned to a KEGG orthologous group, and not all proteins containing RPEL domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR004018