The domain within your query sequence starts at position 473 and ends at position 498; the E-value for the RPEL domain shown below is 5.81e-8.

DTLAIKLGNRPSKKELEDKNILQRTS

RPEL

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

• SMART accession number: SM00707
• Description: -
• Interpro abstract (IPR004018):

  RPEL repeat (RPxxxEL) containing proteins are found in a wide range of metazoan organisms. RPEL repeats have been shown to be required for unpolymerised actin binding and proteins containing RPEL repeats are able to modify cell shape and/or are important in the regulation of gene expression by the actin cytoskeleton. RPEL repeats can be found in association with the SAP motif, which could be involved in DNA binding [ (PUBMED:12732141) (PUBMED:15620697) ].

  Some proteins known to contain RPEL repeats are listed below:

  • Mammalian myocardin, heart-specific serum response factor (SRF) co- activator.
  • Vertebrate myocardin-related transcription factor A (MRTF-A or MAL), a signal-regulated SRF co-activator.
  • Vertebrate myocardin-related transcription factor B (MRTF-B).
  • Mammalian phosphatase and actin regulator 1 to 3.

There are 16001 RPEL domains in 4997 proteins in SMART's nrdb database.

Structure (3D structures containing this domain)

3D Structures of RPEL domains in PDB

PDB code	Title
2v51	Structure of MAL-RPEL1 complexed to actin
2v52	Structure of MAL-RPEL2 complexed to G-actin
2yje	Oligomeric assembly of actin bound to MRTF-A
2yjf	Oligomeric assembly of actin bound to MRTF-A
3tpm	Crystal structure of MAL RPEL domain in complex with importin-alpha
3tpq	Crystal structure of wild-type MAL RPEL domain in complex with five G-actins
4b1u	Structure of the Phactr1 RPEL domain and RPEL motif directed assemblies with G-actin reveal the molecular basis for actin binding cooperativity.
4b1v	Structure of the Phactr1 RPEL-N domain bound to G-actin
4b1w	Structure of the Phactr1 RPEL-2 domain bound to actin
4b1x	Structure of the Phactr1 RPEL-2 bound to G-actin
4b1y	Structure of the Phactr1 RPEL-3 bound to G-actin
4b1z	Structure of the Phactr1 RPEL domain bound to G-actin

Links (links to other resources describing this domain)

• INTERPRO: IPR004018