The domain within your query sequence starts at position 1728 and ends at position 1785; the E-value for the RPT_1 domain shown below is 6.57e-6.

VAPTIKMSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQSLSLGRPRQTT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.