The domain within your query sequence starts at position 1915 and ends at position 2071; the E-value for the RPT_1 domain shown below is 6.6e-9.

DGKLSFWGEHTGQLYSKFLLKAEPLALIVSHDYKGSTSHSLPYESSISTALEHTVSALLT
PAEQTSTWKFKTKLNDKVYSQDFEAYNTKDKIGVELSGRADLSGLYSPIKLPFFYSEPVN
VLNGLEVNDAVDKPQEFTIIAVVKYDKNQDVHTINLP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.