The domain within your query sequence starts at position 218 and ends at position 316; the E-value for the RPT_1 domain shown below is 1.89e-19.

GSVAEQGSRRSSTVEQTRQRGSVAEQGSRRSSTVEQTQRRGSVAEQGSRRSSGVNQTQQR
GSVAEQGSRRSSAVEQTQQRGSVAEQGSRRSSAMEQEPQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.