The domain within your query sequence starts at position 2454 and ends at position 2546; the E-value for the RPT_1 domain shown below is 6.76e-5.

SKGQPTMTTVGSAAVLAGTIKTSVTGTSIPTGTVSGNVIVNTIAGVPAATFQSINKRLAS
PVAPGTLTTSGGSAPAQVVHTQQRAVGSPATAT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.