The domain within your query sequence starts at position 291 and ends at position 354; the E-value for the RPT_1 domain shown below is 2.93e-23.

GSGRKNSSTCGKNGSYSGQSTGRHQQGFGSSHELESGQSITSANHGSHSNQSSCSGTREC
GSSE

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.