The domain within your query sequence starts at position 294 and ends at position 464; the E-value for the RPT_1 domain shown below is 2.76e-22.

DVAASDGSKQNVEDSTLSTGSATSNEGDDKSSDNSSNTFREDLEKILEQITSAPGGSVSS
AVENLKAQIKKFIEPLTEDHGPTSTSASVSGDSSTSSRLDGHSSDGLSKVSGDDPTVQGH
DVAASDGSKQNVEDSTLSTGSATSNEGDDKSSDNSSNTFREDLEKILEQIT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.