The domain within your query sequence starts at position 429 and ends at position 509; the E-value for the RPT_1 domain shown below is 8.34e-9.

HWYATTLQTLMKYPELLSNTQRVYWIAYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFK
EWPLFCQEVEEYHIPALSEAL

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.