The domain within your query sequence starts at position 105 and ends at position 173; the E-value for the RPT_2 domain shown below is 4e-7.

VEEIRKKFEERLRSFGQLQVQFENDKQAALEDLRTTHRLEVQELLKSQQNHSSSVKLGQE
KAEGLHRME

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.