The domain within your query sequence starts at position 2230 and ends at position 2286; the E-value for the RPT_2 domain shown below is 2.78e-6.

PRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.